Ojuami yo | -24°C (tan.) |
Oju omi farabale | 202°C (tan.) 81-82°C/10 mmHg (tan.) |
iwuwo | 1.028 g/mL ni 25 °C (tan.) |
oru iwuwo | 3.4 (pẹlu afẹfẹ) |
oru titẹ | 0.29 mm Hg (20 °C) |
refractive atọka | n20/D 1.479 |
Fp | 187 °F |
iwọn otutu ipamọ. | Fipamọ ni +5°C si +30°C. |
solubility | ethanol: miscible0.1ML/ml, kedere, ti ko ni awọ (10%, v/v) |
fọọmu | Omi |
pka | -0.41± 0.20 (Asọtẹlẹ) |
awọ | ≤20(APHA) |
PH | 8.5-10.0 (100g/l, H2O, 20℃) |
Òórùn | Oorun Amin die |
Iwọn ti PH | 7.7 - 8.0 |
ibẹjadi iye to | 1.3-9.5% (V) |
Omi Solubility | > = 10 g/100 milimita ni 20ºC |
Ni imọlara | Hygroscopic |
o pọju | 283nm (MeOH) (tan.) |
Merck | 14.6117 |
BRN | 106420 |
Iduroṣinṣin: | Idurosinsin, ṣugbọn decomposes lori ifihan si ina.Ijona.Ibamu pẹlu awọn aṣoju oxidizing ti o lagbara, awọn acids ti o lagbara, awọn aṣoju idinku, awọn ipilẹ. |
InChiKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
LogP | -0.46 ni 25 ℃ |
CAS DataBase Reference | 872-50-4(Itọkasi DataBase CAS) |
NIST Kemistri itọkasi | 2-Pyrrolidinone, 1-methyl-(872-50-4) |
Eto Iforukọsilẹ nkan EPA | N-Methyl-2-pyrrolidone (872-50-4) |
Awọn koodu ewu | T,Xi |
Awọn Gbólóhùn Ewu | 45-65-36/38-36/37/38-61-10-46 |
Awọn Gbólóhùn Aabo | 41-45-53-62-26 |
WGK Germany | 1 |
RTECS | UY5790000 |
F | 3-8-10 |
Autoignition otutu | 518 °F |
TSCA | Y |
HS koodu | 2933199090 |
Awọn nkan elewu Data | 872-50-4(Data Awọn nkan ti o lewu) |
Oloro | LD50 ẹnu ni Ehoro: 3598 mg/kg LD50 dermal Ehoro 8000 mg/kg |
Kemikali Properties | N-Methyl-2-pyrrolidone jẹ omi ti ko ni awọ si imọlẹ ofeefee sihin pẹlu oorun amonia diẹ.N-Methyl-2-pyrrolidone jẹ patapata miscible pẹlu omi.O jẹ tiotuka pupọ ni awọn oti kekere, awọn ketones kekere, ether, ethyl acetate, chloroform, ati benzene ati niwọntunwọnsi tiotuka ninu awọn hydrocarbons aliphatic.N-Methyl-2-pyrrolidone jẹ hygroscopic ni agbara, iduroṣinṣin kemikali, kii ṣe ibajẹ si ọna erogba, irin ati aluminiomu, ati ibajẹ diẹ si bàbà.O ni adhesiveness kekere, kemikali to lagbara ati iduroṣinṣin gbona, polarity giga, ati iyipada kekere.Ọja yii jẹ majele ti diẹ, ati opin ifọkansi ti a gba laaye ni afẹfẹ jẹ 100ppm.
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Nlo |
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oloro | Oral (mus) LD50:5130 mg/kg; Oral (eku) LD50:3914 mg/kg; Dermal (rbt) LD50:8000 mg/kg. |
Idasonu Egbin | Kan si ipinlẹ, agbegbe tabi awọn ilana ti orilẹ-ede fun isọnu to dara.Isọnu gbọdọ wa ni ṣiṣe ni ibamu si awọn ilana osise.Omi, ti o ba jẹ dandan pẹlu awọn aṣoju mimọ. |
ibi ipamọ | N-Methyl-2-pyrrolidone jẹ hygroscopic (mu ọrinrin) ṣugbọn iduroṣinṣin labẹ awọn ipo deede.Yoo fesi pẹlu agbara pẹlu awọn oxidizers ti o lagbara gẹgẹbi hydrogen peroxide, nitric acid, sulfuric acid, bbl Awọn ọja jijẹ akọkọ ti nmu monoxide carbon monoxide ati awọn eefin afẹfẹ nitrogen.Ifarahan ti o pọju tabi sisọnu yẹ ki o yago fun bi ọrọ iṣe ti o dara.Ile-iṣẹ Kemikali Lyondell ṣe iṣeduro wọ awọn ibọwọ butyl nigba lilo N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone yẹ ki o wa ni ipamọ ni mimọ, irin ilawọn phenolic tabi awọn ilu alloy.Teflon®1 ati Kalrez®1 ti han lati jẹ awọn ohun elo gasiketi to dara.Jọwọ ṣe ayẹwo MSDS ṣaaju ṣiṣe mimu. |
Apejuwe | N-Methyl-2-pyrrolidone jẹ ohun elo aprotic ti o ni ọpọlọpọ awọn ohun elo: sisẹ petrochemical, ti a bo dada, awọn awọ ati awọn awọ, ile-iṣẹ ati awọn agbo ogun mimọ ile, ati awọn ilana iṣelọpọ ti ogbin ati oogun.O jẹ nipataki irritant, ṣugbọn o tun ti fa ọpọlọpọ awọn ọran ti dermatitis olubasọrọ ni ile-iṣẹ elekitiroki kekere kan. |
Kemikali Properties | N-Methyl-2-pyrrolidone jẹ omi ti ko ni awọ tabi ina pẹlu oorun amine.O le faragba nọmba kan ti awọn aati kẹmika paapaa botilẹjẹpe o ti gba bi olomi iduroṣinṣin.O jẹ sooro si hydrolysis labẹ awọn ipo didoju, ṣugbọn acid to lagbara tabi awọn abajade itọju ipilẹ ni ṣiṣi oruka si 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone le dinku si 1-methyl pyrrolidine pẹlu borohydride.Itoju pẹlu awọn aṣoju chlorinating ni abajade ni dida amide, agbedemeji eyiti o le ṣe aropo siwaju, lakoko ti itọju pẹlu iyọ amọli n mu iyọ jade.Olefins le ṣe afikun si ipo 3 nipasẹ itọju akọkọ pẹlu awọn esters oxalic, lẹhinna pẹlu awọn aldehyes ti o yẹ (Hort and Anderson 1982). |
Nlo | N-Methyl-2-pyrrolidone jẹ epo epo pola ti a lo ninu kemistri Organic ati kemistri polymer.Awọn ohun elo iwọn nla pẹlu imularada ati isọdọmọ ti awọn acetylene, olefins, ati diolefins, isọdi gaasi, ati isediwon aromatics lati awọn ifunni.N-Methyl-2-pyrrolidone jẹ ohun elo ile-iṣẹ to wapọ.NMP ti fọwọsi lọwọlọwọ fun lilo nikan ni awọn oogun oogun.Ipinnu iṣesi ati iṣelọpọ agbara ti NMP ninu eku yoo ṣe alabapin si agbọye majele ti kemikali nla yii eyiti o ṣee ṣe ki eniyan farahan ni awọn oye ti n pọ si. |
Nlo | Solusan fun awọn resini otutu otutu;iṣelọpọ petrochemical, ninu ile-iṣẹ iṣelọpọ microelectronics, awọn awọ ati awọn awọ, ile-iṣẹ ati awọn agbo ogun mimọ ile;ogbin ati elegbogi formulations |
Nlo | N-Methyl-2-pyrrolidone, wulo fun spectrophotometry, chromatography ati wiwa ICP-MS. |
Itumọ | ChEBI: Ọmọ ẹgbẹ ti kilasi ti pyrrolidine-2-ones ti o jẹ pyrrolidin-2-ọkan ninu eyiti hydrogen ti o so mọ nitrogen ti rọpo nipasẹ ẹgbẹ methyl. |
Awọn ọna iṣelọpọ | N-Methyl-2-pyrrolidone jẹ iṣelọpọ nipasẹ iṣesi buytrolactone pẹlu methylamine (Hawley 1977).Awọn ilana miiran pẹlu igbaradi nipasẹ hydrogenation ti awọn ojutu ti maleic tabi succinic acids pẹlu methylamine (Hort ati Anderson 1982).Awọn oluṣelọpọ ti kemikali yii pẹlu Lachat Chemical, Inc, Mequon, Wisconsin ati GAF Corporation, Covert City, California. |
Itọkasi (awọn) Synthesis | Awọn lẹta Tetrahedron, 24, p.Ọdun 1323, Ọdun 1983DOI: 10.1016/S0040-4039(00)81646-9 |
Gbogbogbo Apejuwe | N-Methyl-2-Pyrrolidone (NMP) jẹ alagbara kan, epo aprotic pẹlu iyọti giga, ati iyipada kekere.Aini awọ yii, farabale giga, aaye filasi giga ati omi titẹ oru kekere gbe õrùn amine kekere kan.NMP ni kemikali giga ati iduroṣinṣin gbona ati pe o jẹ aibikita patapata pẹlu omi ni gbogbo awọn iwọn otutu.NMP le ṣiṣẹ bi alapọpọ pẹlu omi, awọn ọti-lile, awọn ethers glycol, awọn ketones, ati awọn hydrocarbons aromatic/chlorinated.NMP mejeeji jẹ atunlo nipasẹ distillation ati ni imurasilẹ biodegradable.A ko rii NMP lori atokọ Awọn Idọti Afẹfẹ eewu (HAPs) ti Awọn Atunse Ofin Mimọ ti 1990. |
Air & Omi aati | Tiotuka ninu omi. |
Profaili Akitiyan | Amin yii jẹ ipilẹ kemikali kekere kan.N-Methyl-2-pyrrolidone ṣọ lati yomi acids lati dagba iyọ pẹlu omi.Iwọn ooru ti o wa fun mole ti amine ni didoju jẹ ominira pupọ si agbara amine gẹgẹbi ipilẹ.Amines le ni ibamu pẹlu isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, ati acid halides.hydrogen gaseous flammable jẹ ipilẹṣẹ nipasẹ amines ni apapo pẹlu awọn aṣoju idinku ti o lagbara, gẹgẹbi awọn hydrides. |
Ewu | Awọ ara ati irritant oju.Awọn ibẹjadi Lim-rẹ 2.2-12.2%. |
Ewu Ilera | Inhalation ti gbona vapors le binu imu ati ọfun.Ingestion fa híhún ti ẹnu ati Ìyọnu.Olubasọrọ pẹlu awọn oju fa ibinu.Tuntun ati ifarakan awọ gigun n ṣe agbejade irẹwẹsi, ibinu igba diẹ. |
Ewu ina | Awọn ewu pataki ti Awọn ọja ijona: Awọn oxides majele ti nitrogen le ṣe agbekalẹ ninu ina. |
Flammability ati Explosibility | Ti ko ni ina |
Awọn lilo ile-iṣẹ | 1) N-Methyl-2-pyrrolidone ti wa ni lilo bi gbogboogbo dipolar aprotic epo, idurosinsin ati aiṣedeede; 2) fun isediwon ti aromatic hydrocarbons lati lubricating epo; 3) fun imukuro erogba oloro ni amonia Generators; 4) bi epo fun awọn aati polymerization ati awọn polima; 5) bi olutọpa kikun; 6) fun awọn agbekalẹ ipakokoropaeku (USEPA 1985). Awọn lilo miiran ti kii ṣe ile-iṣẹ ti N-Methyl-2-pyrrolidone da lori awọn ohun-ini rẹ bi iyọkuro ti o ya sọtọ ti o dara fun awọn imọ-ẹrọ kemikali ati ti ara (Langan and Salman 1987).Awọn ohun elo elegbogi lo awọn ohun-ini ti N-Methyl-2-pyrrolidone gẹgẹbi imudara ilaluja fun gbigbe iyara diẹ sii ti awọn nkan nipasẹ awọ ara (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).N-Methyl-2-pyrrolidone ti fọwọsi bi epo fun ohun elo slimicide si awọn ohun elo iṣakojọpọ ounjẹ (USDA 1986). |
Kan si awọn nkan ti ara korira | N-Methyl-2-pyrrolidone jẹ ohun elo aprotic ti o ni ọpọlọpọ awọn ohun elo: sisẹ petrochemical, ti a bo dada, awọn awọ ati awọn awọ, ile-iṣẹ ati awọn agbo ogun mimọ ile, ati awọn ilana iṣelọpọ ti ogbin ati oogun.Ni akọkọ o jẹ irritant, ṣugbọn o le fa dermatitis olubasọrọ ti o lagbara nitori olubasọrọ gigun. |
Profaili Aabo | Majele nipasẹ ọna iṣan.Niwọntunwọnsi majele ti nipasẹ jijẹ ati awọn ipa-ọna intraperitoneal.Majele ti o niwọnba nipasẹ ifarakan ara.Ohun esiperimenta teratogen.Esiperimenta ipa ibisi.Awọn alaye iyipada ti royin.Ijona nigba ti o ba farahan si ooru, ina ti o ṣii, tabi awọn oxidizers ti o lagbara.Lati ja ina, lo foomu, CO2, kemikali gbẹ.Nigbati o ba gbona si jijẹ, o nmu awọn eefin oloro ti NOx jade. |
Carcinogenicity | Awọn eku ti farahan si N-Methyl-2-pyrrolidone vapor ni 0, 0.04, tabi 0.4 mg / L fun 6 h / ọjọ, 5 ọjọ / ọsẹ fun ọdun 2. Awọn eku ọkunrin ni 0.4 mg / L fihan die-die ti o dinku iwuwo ara.Ko si majele ti kikuru tabi awọn ipa carcinogenic ti a ṣe akiyesi ni awọn eku ti o farahan fun ọdun 2 si boya 0.04 tabi 0.4mg / L ti N-Methyl-2-pyrrolidone.Nipa ọna dermal, ẹgbẹ kan ti awọn eku 32 gba iwọn ibẹrẹ ti 25mg ti N-Methyl-2-pyrrolidone ti o tẹle lẹhin ọsẹ 2 nipasẹ awọn ohun elo ti olupolowo tumo phorbol myristate acetate, ni igba mẹta ni ọsẹ, fun diẹ sii ju ọsẹ 25 lọ.Dimethylcarbamoyl kiloraidi ati dimethylbenzanthracene ṣiṣẹ bi awọn idari rere.Botilẹjẹpe ẹgbẹ N-Methyl-2-pyrrolidone ni awọn èèmọ awọ ara mẹta, idahun yii ko ṣe pataki nigbati a bawe pẹlu ti awọn iṣakoso rere. |
Ọna ti iṣelọpọ | Awọn eku ni a nṣakoso ni redio-aami N-methyl-2- pyrrolidinone (NMP), ati ipa ọna pataki ti iyọkuro nipasẹ awọn eku jẹ nipasẹ ito.Metabolite pataki, ti o nsoju 70-75% ti iwọn lilo ti a nṣakoso, jẹ 4- (methylamino) butenoic acid.Ọja ti ko ni iyọdajẹ yii le ṣe agbekalẹ lati imukuro omi, ati pe ẹgbẹ hydroxyl le wa lori metabolite ṣaaju si hydrolysis acid. |
Ti iṣelọpọ agbara | Awọn eku Sprague-Dawley ọkunrin ni a fun ni abẹrẹ intraperitoneal kan (45 mg/kg) ti radiolabeled 1 -methyl-2-pyrrolidone.Awọn ipele pilasima ti ipanilara ati agbo ni a ṣe abojuto fun wakati mẹfa ati awọn abajade daba ipele pinpin iyara kan eyiti o tẹle nipasẹ ipele imukuro o lọra.Iye pataki ti aami ni a yọ jade ninu ito laarin awọn wakati 12 ati pe o fẹrẹ to 75% iwọn lilo aami.Wakati mẹrinlelogun lẹhin iwọn lilo, iyọkuro akopọ (ito) jẹ isunmọ 80% ti iwọn lilo.Mejeeji oruka- ati awọn eya aami methyl ni a lo, ati awọn mejeeji [14C] - ati [3H] -aami l-methyl-2-pyrrolidone.Awọn ipin aami akọkọ ti wa ni itọju lakoko awọn wakati 6 akọkọ lẹhin iwọn lilo.Lẹhin awọn wakati 6, ẹdọ ati awọn ifun ni a rii lati ni awọn ikojọpọ ti o ga julọ ti ipanilara, to 2-4% ti iwọn lilo.Iṣẹ ipanilara kekere ni a ṣe akiyesi ni bile tabi afẹfẹ atẹgun.Kiromatografi omi ti o ga julọ ti ito ṣe afihan wiwa pataki kan ati awọn metabolites kekere meji.Metabolite pataki (70-75% ti iwọn lilo ipanilara ti a nṣakoso) ni a ṣe atupale nipasẹ chromatography-mass spectrometry ati gaasi chromatography-mass spectrometry ati pe a daba lati jẹ 3- tabi 5-hydroxy-l-methyl-2-pyrrolidone (Wells). Ọdun 1987). |
Awọn ọna ìwẹnumọ | Gbẹ pyrrolidone nipa yiyọ omi kuro bi * benzene azeotrope.Fractionally ditil ni 10 torr nipasẹ kan 100-cm iwe aba ti pẹlu gilasi helices.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Awọn hydrochloride ni o ni m 86-88o (lati EtOH tabi Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.] |