Di-tert-butyl dicarbonate

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Orukọ ọja:Di-tert-butyl dicarbonate

Awọn itumọ ọrọ sisọ:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride,ragidi/olomi.

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Awọn ẹka ọja:Awọn agbedemeji elegbogi; Bibẹrẹ Awọn ohun elo Raw & Awọn agbedemeji; Awọn itọsẹ Amino Acid; Awọn ẹya ara ẹrọ; Awọn Reagents Idaabobo N-Idaabobo; Biokemisitiri; Peptide Synthesis; Aabo & Awọn isọdọtun itọsẹ (fun Synthesis); Awọn oludabobo Aabo (Asọpọ peptide Synthesis); Awọn atunbere fun Oligsisacsis Boc-Amino acid jara; Oriṣiriṣi Reagents; DIBOC; 1H-Inden-1-ol; bc0001; 24424-99-5

Faili Mol:24424-99-5.mol

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ọja Tags

Di-tert-butyl dicarbonate Kemikali Properties

Ojuami yo	23°C (tan.)
Oju omi farabale	56-57°C/0.5 mmHg (tan.)
iwuwo	0.95 g/mL ni 25 °C (tan.)
oru titẹ	3.85Pa ni 25 ℃
refractive atọka	n20/D 1.409(tan.)
Fp	99 °F
iwọn otutu ipamọ.	2-8°C
fọọmu	Kekere Yo Kirisita Ri to
awọ	funfun
Specific Walẹ	0.950
Omi Solubility	Miscible pẹlu decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile ati dimethylformamide.Immiscible pẹlu omi.
Ni imọlara	Ọrinrin Sensitive
BRN	Ọdun 1911173
InChiKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 ni 25 ℃
CAS DataBase Reference	24424-99-5(Itọkasi DataBase CAS)
Eto Iforukọsilẹ nkan EPA	Dicarbonic acid, bis (1,1-dimethylethyl) ester (24424-99-5)

Alaye Aabo

Awọn koodu ewu	T+,T,F,Xi,F+
Awọn Gbólóhùn Ewu	11-19-26-36/37/38-43-10-40
Awọn Gbólóhùn Aabo	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Germany	3
RTECS	HT0230000
F	4.4-10-21
Autoignition otutu	460 °C
Akọsilẹ ewu	Flammable/Irritant/Majele pupọ
TSCA	Bẹẹni
Kilasi Hazard	6.1
Ẹgbẹ Iṣakojọpọ	I
HS koodu	29209010
Oloro	LD50 ẹnu ni Ehoro:> 5000 mg/kg LD50 dermal Ehoro> 2000 mg/kg

Di-tert-butyl dicarbonate Lilo Ati Afopọ

Kemikali Properties	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) jẹ awọ ti ko ni awọ si funfun si awọn kirisita ofeefee, ibi-ara ti o fẹsẹmulẹ tabi omi mimọ.O yo ni ayika iwọn otutu yara (mp=23°C).Ko decompose ni yi tabi paapa die-die ti o ga awọn iwọn otutu.Fun apẹẹrẹ, o jẹ mimọ nigbagbogbo nipasẹ distillation labẹ titẹ idinku ni awọn iwọn otutu to 65°C.Ni awọn iwọn otutu ti o ga julọ yoo decompose si isobutene, t-butyl oti ati erogba oloro.
Nlo	Di-tert-butyl dicarbonate (Boc2O) jẹ reagent ti a lo lọpọlọpọ fun iṣafihan awọn ẹgbẹ aabo ni iṣelọpọ peptide.O ṣe ipa pataki ni igbaradi ti 6-acetyl-1,2,3,4-tetrahydropyridine nipa ṣiṣe pẹlu 2-piperidone.O ṣe iranṣẹ bi ẹgbẹ aabo ti a lo ninu iṣelọpọ peptide alakoso to lagbara.
Igbaradi	Igbaradi ti Di-tert-butyl dicarbonate jẹ bi atẹle: Si ojutu iyọ iṣuu soda monoester ni a ṣafikun 2g ti N, N-dimethylformamide, 1g ti pyridine, 1g ti triethylamine, Itutu si -5 ~ 0 ° C, 60g diphosgene jẹ laiyara. fi kun dropwise laarin 1.5h dropwise afikun ti pari, warmed si yara otutu (25°C), incubated fun 2h, awọn lenu ti a gba ọ laaye lati duro lẹhin ase, fifọ Organic ojutu.Ti o gbẹ pẹlu imi-ọjọ iṣuu magnẹsia anhydrous, epo ti a distilled ni pipa ni titẹ oju aye lati fun ọja robi 65 ~ 70g.Lẹhin itutu agbaiye ati crystallization, 57-60g ti di-tert-butyl dicarbonate ni a gba ni ikore ti 60-63%.
Itumọ	ChEBI: Di-tert-butyl dicarbonate jẹ acyclic carboxylic anhydride.O ni ibatan si iṣẹ ṣiṣe si dicarbonic acid.
Awọn aati	Idahun ti anilines ti o rọpo pẹlu Boc2O niwaju iwọn stoichiometric ti 4-dimethylaminopyridine (DMAP) ninu ohun elo inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) ni iwọn otutu yara nyorisi awọn isocyanates aryl ni o fẹrẹ to laarin iye-iye. min. Di-tert-butyl dicarbonate ati 4- (dimethylamino) pyridine tun wo.Wọn aati pẹlu amines ati alcohols
Gbogbogbo Apejuwe	Di-tert-butyl dicarbonate (Boc₂O) jẹ reagent ti a lo ni akọkọ fun iṣafihan ẹgbẹ aabo Boc si awọn iṣẹ ṣiṣe amine.O tun lo bi oluranlowo gbígbẹ ni diẹ ninu awọn aati Organic, pataki pẹlu awọn acids carboxylic, awọn ẹgbẹ hydroxyl kan, tabi pẹlu awọn nitroalkanes akọkọ.
Ewu	Irritant ti o le fa ipalara oju nla;Le fa ifamọ awọ ara;Majele ti o ga julọ nipasẹ ifasimu
Flammability ati Explosibility	Flammable
Awọn ọna ìwẹnumọ	Yo ester naa nipasẹ alapapo ni ~ 35o, ki o si sọ ọ sinu igbale.Ti IR ati NMR (1810m 1765 cm-1, ni CCl4 1.50 singlet) daba pupọ julọ alaimọ, lẹhinna wẹ pẹlu iwọn dogba ti H2O ti o ni citric acid lati jẹ ki Layer olomi jẹ ekikan diẹ, gba Layer Organic ati ki o gbẹ lori anhydrous MgSO4 ki o si ditil o ni igbale.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] FLAMMABLE.